It can also be stored in the liver when it is administered in large amounts that confer warfarin resistance to the patient for several periods of time. Therefore, vitamin KH2 is available for carboxylation without the need for vitamin KO reductase. The effect of warfarin can be overestimated by the administration of vitamin K1 (phytonadione) as a medication or through diet. This reduces the blood’s clotting activity by reducing the production of vitamin K-dependent factors. Warfarin inhibits vitamin KO reductase and, therefore, limits the availability of vitamin K in the cyclic response. This is done by blocking the formation of coagulation factors necessary for coagulation. Warfarin works by preventing your body from forming blood clots. Menstrual bleeding or vaginal bleeding more intense than normal.

Bleeding from cuts that take a long time to stop.Stroke, systemic embolization after myocardial infarction.Thromboembolic complications due to atrial fibrillation or valvular cardiac replacement.Venous thrombosis and pulmonary embolism.It can be used for the prophylaxis and treatment of Warfarin has more clinical applications approved by the FDA and off label. Warfarin is an oral anticoagulant that is commonly used to treat and prevent blood clots. Antidotes for Warfarin are those agents which reverse the effects of toxicity of warfarin.

Antidote coumadin overdose